AFTER FREEZE-DRYING USING AN INNOVATIVE LYOPROTECTANT
[SCIENTIFIC POSTER]
Viability and vitality are crucial criteria when considering probiotics. Indeed, to ensure a good efficacy of the living products, manufacturers must guarantee a minimal count of viable bacteria at the end of the shelf life. Reaching a high number of viable cells at the end of the production process and maintaining it until the end of product shelf life is thus one of the biggest challenge for probiotic producers.
Freeze-drying is a widely used technique for stabilizing probiotics. Nonetheless probiotic manufacturers can commonly undergo very high viability losses at this step (Morgan et al. 2006 and Santivarangkna et al. 2006). Several approaches exist to address this challenge, such as optimizing the selection of the lyoprotectant.
In this study, the impact of two lyoprotectants, maltodextrin and NuCel® Protect 501, over Bifidobacterium animalis subsp. lactis (DSM 10140) viability, vitality and activity were evaluated after freeze-drying and over a year. The subsequent viability evolution was predicted with a proprietary modelling tool (Predict). Scanning Electron Microscopy (SEM) was finally used to study the lyophilizates structure.
Download the scientific poster now to learn more about the NuCel® range ability to enhance long-term viability and vitality of probiotics strains after freeze-drying!
