MERCK & PROCELYS
STRATEGIC COLLABORATION TO BUILD SUSTAINABLE BIOTECH PERFORMANCE


This page extends the conversation from Suppliers' Day 2026. Explore the technical proof behind our three collaboration pillars and discover how yeast-based nutrients drive measurable outcomes for Life Science and Health Care.

A GLOBAL PARTNER, A LOCAL ALLY

Collaboration with Procelys by Lesaffre is more than just a concept—it’s a dynamic process leading to real-world results. Through open dialogue, co-creation, and continuous optimization, we turn shared visions into solutions that align with your strategic goals. With each step, we prioritize delivering outcomes aligned with research innovation, operational efficiency, and sustainable practices.

3 CORE DRIVERS FOR A STRATEGIC COLLABORATION

SCIENCE-POWERED INNOVATION
Bringing ideas ​to life​


Deep expertise in biology and fermentation,
cutting-edge technologies, and data-driven
approaches to co-create the innovative
solutions you need.

 

GLOBAL REACH, LOCAL FOCUS​
Catalyzing fitting solutions everywhere

 
Faster responses, smoother collaboration, and 
tailored support for R&D to operation teams.

 
SUSTAINABILITY IN ACTION
Accelerate the trajectory


A common vision and yeast-based solutions, as 
strong foundations to contribute to your
sustainability goals. ​
SCIENCE-POWERED INNOVATION
At Procelys by Lesaffre, we combine yeast expertise, advanced analytics, and a deep understanding of microorganisms to enhance fermentation processes that feed living microorganisms and unlock their full potential.
 

Microorganism insight - Tailored nutrition for specific microbial needs (i.e: P. pastoris, S. cerevisiae, E. coli and more).
 

A CASE OF STRICT ANAEROBIC PROTOCOLS WITH AMBITION TO DEVELOP ANIMAL-FREE SOLUTION
 

From Nutritional Needs of Anaerobic Microorganisms to Optimal Nitrogen Nutrients for Gut Microbiome Therapeutics

Protocol:

  1. Yeast-based nutrient selection.
  2. Bioreactor validation.
  3. Assessment of the Biotic potential of yeast-based nutrient-grown F. prausnitzii.
  4. Mucus-simulator of human intestinal microbial ecosystem (SHIME).
Gas and inoculation selection in bioreactor
Kinetics of substrate consumption & main metabolites
production over 48h
Strict anaerobic bioreactor conditions were evaluated using CO₂ or N₂ atmospheres and 1% or 10% inoculation. pH kinetics, glucose consumption, and metabolite production demonstrate that gas selection drives fermentation kinetics, enabling reproducible, animal-free anaerobic processes.

Read this article for more details

 

A Case of Optimization of Liquid Culture Media for the Detection and Screening of Pseudomonas aeruginosa

Increase of time to results through faster and higher growth resulting in a shorter time to reach detection threshold.
 

Alternative to animal peptones: analytical based recommendation of the more relevant yeast-based nutrient resulting in an efficient substitution.
 

YEAST PEPTONES – A COMPLEMENTARY ADDITION TO THE PEPTONE LANDSCAPE 
With their uniquely designed composition, yeast peptones are essential for supporting the growth of various microorganism species in a wide range of culture media. They can be used alone or synergistically with meat and vegetable peptones to optimize the production of biopharmaceuticals such as biologicals, active pharmaceutical ingredients (API), and vitamins by recombinant and non-recombinant microorganisms. Alternatively, yeast peptones offer an ideal replacement for traditional peptones, enabling producers to create animal-free and allergen-free.​

[article] What are yeast peptones?

[article] What are the advantages of yeast peptones in the fermentation process?

DEDICATED OFFER FOR BIOPHARMA
Ideal for manufacture of a range of biopharma products, including antibodies, antibiotics, vaccines, vitamins, and ready-to-use media, when you use ProCel® – our high-performance fermentation nutrients specifically designed for the biopharma industry.

More information about our
 
Biopharma Solutions from Fermentation
More information about our
Biopharma Microbiome Applications
GLOBAL REACH, LOCAL FOCUS
From R&D to industrial scale, Procelys supports your projects with a structured, end-to-end partnership model.

How we collaborate, we partner closely with our customers through:
•    Co‑development - with joint R&D from concept through validation.
•    Proof of concepts - generating validated performance data in our application labs.
•    Quality alignment - managing critical parameters (such as endotoxins and nitrogen), ensuring batch‑to‑batch consistency, and formalizing quality agreements.
•    A global network - with 7 manufacturing sites that secure supply resilience.
•    Sustainability integration - embedded in every collaboration.

We welcome the opportunity to partner with you to leverage advanced technologies from the very inception of our innovation initiatives.

 ​​​​

ILLUSTRATION OF PROOF-OF-CONCEPTS

Recombinant enzyme production optimization with yeast extract in P. pastoris

This experiment shows how yeast-based nutrients enriched protein production.
P. pastoris, grown in bioreactor, expressing Human Serum Albumin (HSA) on plasmid under control of the constitutive GAP promoter in chemically defined media with 8% of ProCel® 245 MG. The recombinant HSA yield increased 88% when the media is supplemented with a ProCel® 245 MG yeast extract.

Comparaison of biomass & recombinant protein production after 15h of growth

Results obtained for genetically modified Saccharomyces cerevisie strain producing GFP. ​The strain was grown in Micro Titer Plate at 28°C under agitation with 10 g/L Soy Peptone or Yeast Peptone 3 - in a culture media derived from CP broth.​ Better performance are observed with the yeast peptone.

Animal-free alternative to casein peptone for TSA formulations

Yeast peptone products can serve as an animal-free alternative to casein peptones in standard TSA formulations, while maintaining equivalent microbial performance compared to commercial TSA used as the reference control.

 

B.subtilis ATCC 6633

Sauries - ATCC 6538

Across all three strains, Procelys animal-free peptones deliver growth comparable to casein peptones and TSA, confirming equivalent performance at 24h.

C.albicans - ATCC 10231

​​​​QUALITY & COMPLIANCE ALIGNMENT
We adapt the quality and compliance alignment with end application market, fueled by market insights , and of course customer specificities.
 
SUSTAINABILITY IN ACTION : ACCELERATE THE TRAJECTORY
A common vision and yeast-based solutions, as strong foundations to contribute to your sustainability goals. Procelys by Lesaffre, as part of the Lesaffre group, considers sustainability as a key driver, as we for our collaborative innovation projects,​ focus on climate change targets.
STRATEGIC OUTCOMES FOR MERCK

Cross-BU Collaboration

Solutions spanning
Life science and health care

Accelerated Time-to-Market

Co-creation projects from R&D
through industrial validation

End-to-End Partnership

From co-development to quality
alignement and sustainability

Portfolio Diversification

Tailored solutions to strengthen
market competitiveness

Advanced Technologies

Access to R&D pipeline
and analytical platforms

Supply Chain Resilience

7 global sites ensuring
reliable supply and compliance
YOUR BIOTECH PARTNER